Out‐of‐Equilibrium Self‐Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators

Among the key characteristics of living systems are their ability to self-replicate and fact that they exist in an open system away from equilibrium. Herein, we show how outcome competition between two self-replicators, differing size building block composition, is different depending on whether experiments conducted a closed vial or out-of-equilibrium replication–destruction regime. In system, slower replicator eventually prevails over faster competitor. replication-destruction regime, implemented through flow reversed dominates. The interpretation experimental observations supported by mass-action-kinetics model. These results represent one few manifestations selection among competing self-replicators based dynamic kinetic stability pave way towards Darwinian evolution abiotic systems.